A

METHOD FOR DETECTING LUPUS NEPHRITIS

Espacenet Family 68424566

Abstract

[0001] The present invention relates to a method for diagnosing lupus nephritis in an individual suffering from systemic lupus erythematosus (SLE), said method conducted in vitro comprising identifying a protein that comprises an YB-1-like cold-shock domain which bears one or more guanidinylated lysinyl moieties (YB-1-G) in a sample S obtained from the individual. Furthermore, the present invention also refers to treating or preventing lupus nephritis in an individual, wherein lupus nephritis has been diagnosed in the individual by means of a method of the present invention. [0002] La présente invention concerne un procédé de diagnostic du lupus néphrétique chez un individu souffrant de lupus érythémateux systémique (LES), ledit procédé mis en uvre in vitro comprenant l'identification d'une protéine qui comprend un domaine de choc froid de type YB-1 qui porte une ou plusieurs entités lysinyles guanidinylées (YB-1-G) dans un échantillon S obtenu à partir de l'individu. En outre, la présente invention concerne également le traitement ou la prévention du lupus néphrétique chez un individu, le lupus néphrétique ayant été diagnostiqué chez l'individu au moyen d'un procédé selon la présente invention.

Inventors 7

  1. Ute Raffetseder Aachen author as filed: Raffetseder, Ute
  2. Daniel M. Breitkopf Aachen author as filed: Breitkopf, Daniel
  3. Thomas Rauen Aachen author as filed: Rauen, Thomas
  4. Vera Jankowski Aachen author as filed: Jankowski, Vera
  5. Floege, Jurgen
  6. Tammo Ostendorf Aachen author as filed: Ostendorf, Tammo
  7. Floege, Jürgen

Inventors are linked to an Aachen author when surname and first name match exactly one author.

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