POLYPEPTIDE CONJUGATES

Abstract

Disclosed herein is are conjugates that comprise a ubiquitin dimer or multimer, comprising a distal moiety conjugated to a proximal moiety. The distal moiety comprises a polypeptide comprising a distal ubiquitin at its C-terminus, said ubiquitin comprising at least one of the following mutations: K6X, K11X, K27X, K29X, K33X, K48X, K48X, K63X, or K63X, where X is selected from R, A or C. The proximal moiety comprises a polypeptide comprising either a proximal ubiquitin at its C-terminus or a proximal ubiquitin at its N-terminus; said ubiquitin comprising a blocked C-terminus. The distal moiety is conjugated to the proximal moiety via an amide bond from G76 of the distal ubiquitin to one of M1, K6, K11, K27, K29, K33, K48, or K63 of the proximal ubiquitin. Also provided are methods for the production of said conjugates, formulations comprising said conjugates and methods of using said conjugates.

Inventors 7

1. Scheeren, Dhr. Ferenc Alexander
2. Ovaa, Dhr. Huib
3. El Hebieshy, Mw. Angela Fouad
4. El, Hebieshy Mw Angela Fouad
5. Ferenc A. Scheeren Aachen author as filed: Scheeren, Ferenc, Alexander
6. Huib Ovaa Aachen author as filed: Ovaa, Huib
7. El Hebieshy, Angela Fouad

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

• ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden

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