MuSK activation
Espacenet
Family 63966029
Abstract
Novel methods for treating a condition or disorder associated with impaired neuromuscular transmission, such as MuSK myasthenia gravis (MuSK MG), in a subject are provided herein. Novel methods for treating a symptom associated with impaired neuromuscular transmission in a subject are also provided. The invention also provides mu|tiva|ent binding agents for use in treating the same.
Inventors 4
- Silvère, Maria van der Maarel
- Johannes, Justus Gerard Maria Verschuuren
- Martina, Gerardina Maria Huijbers
- Jakob, Jan Plomp
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- ACADEMISCH ZIEKENHUIS LEIDEN (H.O.D.N. LUMC) GBS Leiden
Cited papers 6 in the database
Non-patent literature as cited (7)
- - SARAH CANTOR ET AL: "Preserving neuromuscular synapses in ALS by stimulating MuSK with a therapeutic agonist antibody", ELIFE, vol. 7, 20 February 2018 (2018-02-20), XP055587207, DOI: 10.7554/eLife.34375
- - MORI SHUUICHI ET AL: "Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis", JOURNAL OF NEUROIMMUNOLOGY, vol. 244, no. 1, 1 January 2012 (2012-01-01), pages 1 - 7, XP028903355, ISSN: 0165-5728, DOI: 10.1016/J.JNEUROIM.2011.12.005
- - KONECZNY INGA ET AL: "IgG4 autoantibodies against muscle-specific kinase undergo Fab-arm exchange in myasthenia gravis patients", JOURNAL OF AUTOIMMUNITY, LONDON, GB, vol. 77, 10 December 2016 (2016-12-10), pages 104 - 115, XP029897113, ISSN: 0896-8411, DOI: 10.1016/J.JAUT.2016.11.005
- - JAN J.G.M. VERSCHUUREN ET AL: "Passive transfer models of myasthenia gravis with muscle-specific kinase antibodies : MuSK MG passive transfer", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1413, no. 1, 21 January 2018 (2018-01-21), US, pages 111 - 118, XP055587218, ISSN: 0077-8923, DOI: 10.1111/nyas.13543
- - MAARTJE G. HUIJBERS ET AL: "IgG4-mediated autoimmune diseases: a niche of antibody-mediated disorders : IgG4-mediated autoimmune diseases", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 1413, no. 1, 28 January 2018 (2018-01-28), US, pages 92 - 103, XP055587211, ISSN: 0077-8923, DOI: 10.1111/nyas.13561
- - MASAHARU TAKAMORI: "Structure and function of neuromuscular junction, centered on muscle-specific tyrosine kinase and related proteins", CLINICAL AND EXPERIMENTAL NEUROIMMUNOLOGY, vol. 7, no. 3, 1 August 2016 (2016-08-01), pages 215 - 225, XP055587248, ISSN: 1759-1961, DOI: 10.1111/cen3.12314
- - MAARTJE G. HUIJBERS ET AL: "MuSK myasthenia gravis monoclonal antibodies : Valency dictates pathogenicity", NEUROLOGY - NEUROIMMUNOLOGY NEUROINFLAMMATION, vol. 6, no. 3, 21 February 2019 (2019-02-21), pages e547, XP055585991, DOI: 10.1212/NXI.0000000000000547