BIOACTIVE PEPTIDES DERIVED FROM SNAKES
Espacenet
Family 63637795
Abstract
The disclosure concerns snake derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
Inventors 7
- Harald M. I. Kerkkamp Aachen author as filed: Kerkkamp, Harald Martijn IJsbrand
- Michael K. Richardson Aachen author as filed: Richardson, Michael Keith
- Gilles P. van Wezel Aachen author as filed: van Wezel, Gilles Philippus
- Jan Wouter Drijfhout Aachen author as filed: Drijfhout, Jan Wouter
- Robert A. Cordfunke Aachen author as filed: Cordfunke, Robert Alexander
- Michella M. Voet Aachen author as filed: Voet, Michella Manon
- Nibbering, Petrus Hendricus
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- UNIVERSITEIT LEIDEN GBS Leiden
Cited papers 5 in the database
Non-patent literature as cited (21)
- - DE KRAKER ET AL., O'NEILL 2016, 2016
- - BRAUNER ET AL.: "Distinguishing between resistance, tolerance and persistence to antibiotic treatment", NATURE, vol. 14, 2016, pages 321 - 330
- - ROSENVINGE ET AL.: "Microbial biofilms and gastrointestinal diseases", PATHOG DIS., vol. 67, no. 1, 2013, pages 25 - 38
- - BAHAR AAREN D: "Antimicrobial peptides", PHARMACEUTICALS, vol. 6, 2013, pages 1543 - 1575, XP055469010, DOI: 10.3390/ph6121543
- - BOUCHER HWTALBOT GH ET AL.: "Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America", CLIN. INFECT. DIS., vol. 48, 2009, pages 1 - 12
- - CAI SQIAO X ET AL.: "Python cathelicidin CATHPbl protects against multidrug-resistant staphylococcal infections by antimicrobial-immunomodulatory duality", J. MEDICINAL CHEMISTRY, vol. 61, 2018, pages 2075 - 2086
- - CHO YCLEE SH ET AL.: "Enhanched IL-12p40 production in LPS-stimulated macrophages by inhibiting JNK activation by artemisinin", ARH. PHARM. RES., vol. 35, 2012, pages 1951 - 1968
- - DE KRAKER MEASTEWARDSON AJHARBARTH S: "Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?", PLOS MED., 2016
- - DE LATOUR FAAMER LS ET AL.: "Antimicrobial activity of the Naja atra cathelicidin and related small peptides", BBRC, vol. 396, 2010, pages 825 - 830
- - DEAN SN ET AL.: "Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus", BMC MICROBIOLOGY, 2011
- - FALCAO CB ET AL.: "Vipericidins; a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers", AMINOACIDS, vol. 46, 2014, pages 2561 - 2571
- - HOIBY NBJARNSHOLT T ET AL.: "Antibiotic resistance of bacterial biofilms", INTERNATIONAL J. ANTIMICROBIAL AGENTS, vol. 35, 2010, pages 322 - 332, XP026915279, DOI: 10.1016/j.ijantimicag.2009.12.011
- - KOSCIUCZUK EMLISOWSKI P ET AL.: "Cathelicidins: family of antimicrobial peptides. A review", MOL. BIOL. REP., vol. 39, 2012, pages 10957 - 10970, XP035132916, DOI: 10.1007/s11033-012-1997-x
- - O'NEILL, TACKLING DRUG-RESISTANT INFECTIONS GLOBALLY: FINAL REPORT AND RECOMMENDATIONS, 2016, Retrieved from the Internet <URL:https://amr-review.org/sites/default/files/160518_Final%20paper_with%20cover.pdf>
- - OLSEN I: "Biofilms-specific antibiotic tolerance and resistance", EUR. J. CLIN. MICROBIOL. INFECT. DIS., vol. 34, 2015, pages 877 - 886, XP035493243, DOI: 10.1007/s10096-015-2323-z
- - OVERHAGE JCAMPISANO A ET AL.: "Human host defense peptide LL-37 prevents bacterial biofilm formation", INFECT. IMMUN., vol. 76, 2008, pages 4176 - 4182, XP055046917, DOI: 10.1128/IAI.00318-08
- - SCOTT MGDAVIDSON DJ ET AL.: "The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses", J. IMMUNOL., vol. 169, 2002, pages 3883 - 3891, XP002250232
- - SHEK KCTSUI KL ET AL.: "Oral bacterial flora of the Chinese cobra (Naja atra) and bamboo pit viper (Trimeresurus albolabris) in Hong Kong SAR, China", HONG KONG MED. J., vol. 15, 2009, pages 183 - 190
- - VAN DER DOES AM ET AL.: "LL-37 directs macrophage differentiation toward macrophages with a pro-inflammatory signature", J. IMMUNOL., vol. 185, 2010, pages 1442 - 1449
- - WANG H ET AL.: "BF30 selectively inhibits melanoma cell proliferation via cytoplasmic membrane permeabilization and DNA-binding in vitro and in B16F10-bearing mice", EUR. J. PHARMACOL., vol. 707, 2013, pages 1 - 10
- - ZHAO FLAN XQ ET AL.: "King cobra peptide OH-CATH30 as a potential candidate drug through clinic drug-resistant isolates", ZOOLOGICAL RESEARCH., vol. 39, 2018, pages 87 - 96