System and method for en masse patterning of molecule structures
Abstract
Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be connected by parking chambers. The systems and methods can utilize the geometry of the devices in coordination with a voltage application routine to park nucleic acid molecules in the parking chambers and subsequently inject the nucleic acid molecules into the nanoslits. The methods can be utilized to present nucleic acid molecules in a fashion suitable for genomic analysis. The methods can also be utilized to provide size selection of the nucleic acid molecules.
Inventors 7
- Schwartz, David Charles
- Kounovsky-Shafer, Kristy L.
- Hernandez-Ortiz, Juan Pablo
- Potamousis, Konstantinos Dimitrios
- De Pablo, Juan Jose
- Theo Odijk Aachen author as filed: Odijk, Theo
- Jo, Kyubong
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- Wisconsin Alumni Research Foundation
- University of Leiden GBS Leiden
- University of Chicago
- Wisconsin Alumni Res Found
- Univ Chicago
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