CONDITIONALLY IMMORTALIZED CELLS AND METHODS FOR THEIR PREPARATION

Abstract

The present disclosure relates to genetically modified conditionally immortalized cells and cell lines, provided with a vector comprising a promoter sequence, at least one immortalization gene operably linked to the promoter sequence, a gene coding for an inducible regulator operably linked to the promoter sequence and a response element for the inducible regulator. The present disclosure further relates to methods for their preparation, and to immortalization and differentiation of such cells.

Inventors 3

1. de Vries, Antonius Andrianus Franciscus
2. Daniël A. Pijnappels Aachen author as filed: Pijnappels, Daniel Antonie
3. Schaly, Martin Jan

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

• Academisch Ziekenhuis Leiden h.o.d.n. LUMC GBS Leiden

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