MODULATION OF CILIOGENESIS
Espacenet
Family 55132918
Abstract
The disclosure is based on the finding that compounds capable of binding to (or interacting with) chromatin binding/remodelling complexes (for example Polycomb group PRC1 and Trithorax group MLL) and/or modulation of the same can be used to modulate (for example switch on/off) ciliogenesis as may occur, for example, in the human pulmonary bronchial epithelium. Provided are compounds, compositions, methods and medicaments which may be used to treat and/or prevent diseases and/or conditions associated with aberrant or defective ciliogenesis.
Inventors 1
- Van Brempt, Ronald Karel Louisa
Inventors are linked to an Aachen author when surname and first name match exactly one author.
Applicants
- Academisch Ziekenhuis Leiden a/u Leiden University Medical Center GBS Leiden
Cited papers 0 in the database
Non-patent literature as cited (2)
- - Veazy et al. (Alc Res:Current Reviews, 2013;35(1):77-85) (Year: 2013)
- - Arkin MR, Glicksman MA, Fu H, et al. Inhibition of Protein-Protein Interactions: Non-Cellular Assay Formats. 2012 Mar 18. In: Markossian S, Grossman A, Arkin M, et al., editors. Assay Guidance Manual. Bethesda (MD): Eli Lilly & Co (Year: 2012)