System and method for presenting large DNA molecules for analysis

Abstract

[0001] Systems and methods for presenting nucleic acid molecules for analysis are provided. The nucleic acid molecules have a central portion that is contained within a nanoslit. The nanoslit contains an ionic buffer. The nucleic acid molecule has a contour length that is greater than a nanoslit length of the nanoslit. An ionic strength of the ionic buffer and electrostatic or hydrodynamic properties of the nanoslit and the nucleic acid molecule combining to provide a summed Debye length that is greater than or equal to the smallest physical dimension of the nanoslit.

Inventors 6

1. Schwartz, David C.
2. Kounovsky-Shafer, Kristy
3. Hernandez-Ortiz, Juan
4. Theo Odijk Aachen author as filed: Odijk, Theo
5. DePablo, Juan
6. Jo, Kyubong

Inventors are linked to an Aachen author when surname and first name match exactly one author.

Applicants

• Wisconsin Alumni Research Foundation
• University of Leiden GBS Leiden
• University of Chicago
• Wisconsin Alumni Res Found
• Univ Chicago

Cited papers 0 in the database

Non-patent literature as cited (18)

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Cited patents 3